Pharmaniaga Metronidazole Indications/Uses

Metronidazole is indicated for the treatment of symptomatic trichomoniasis in females and males when the presence of trichomonad has been confirmed by appropriate laboratory procedures (wet smears and/or cultures). Since there is evidence that presence of the trichomonad can interfere with accurate assessment of abnormal cytological smears, additional smears should be performed after eradication of the parasite.
T. vaginalis infections is a venereal disease. Therefore, asymptomatic sexual partners of treated patients should be treated simultaneously if the organism has been found to be present, in order to prevent reinfection of the partner. The decision as to whether to treat an asymptomatic male-partner who has negative culture or one for whom no culture has been attempted is an individual one. In making this decision, it should be noted that there is evidence that a woman may become reinfected if her consort is not treated. Also, since there can be considerable difficulty in isolating the organism from the asymptomatic male carrier, negative smears and cultures cannot be relied upon in this regard. In any event, the consort should be treated with metronidazole in cases of reinfection.
Metronidazole is indicated in the treatment of acute intestinal amoebiasis (amoebic dysentery) and amoebic liver abscess. In amoebic liver abscess, metronidazole therapy does not obviate the need for aspiration or drainage of pus.
Metronidazole is indicated in the treatment of serious infections caused by susceptible anaerobic bacteria. Indicated surgical procedures should be performed in conjunction with metronidazole therapy. In a mixed aerobic and anaerobic infection, antimicrobials appropriate for the treatment of the aerobic infection should be used in addition to metronidazole. In the treatment of most serious anaerobic infections, intravenous metronidazole is usually administered initially. This may be followed by oral therapy at the discretion of the physician.
Intra-abdominal infections, including peritonitis, intra-abdominal abscess, and liver abscess caused by Bacteroides species including the B. fragilis group (B. fragilis, B. distasonis, B. ovatus, B. thetaiotaomicron, B. vulgatus), Clostridium species, Eubacterium species, Peptococcus niger or Peptostreptococcus species.
Skin and skin structure infections caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus niger, Peptostreptococcus species or Fusobacterium species.
Gynaecologic infections including endometritis, endomyometritis, tubo-ovarian abscess, and postsurgical vaginal cuff infection, caused by Bacteroides species including the B. fragilis group, Clostridium species, Peptococcus niger or Peptostreptococcus species.
Bacterial septicaemia caused by Bacteroides species including the B. fragilis group or Clostridium species.
Bone and joint infections (as adjunctive therapy) caused by Bacteroides species including the B. fragilis group.
Central nervous system (CNS) infections, including meningitis and brain abscess, caused by Bacteroides species including the B. fragilis group.
Endocarditis caused by Bacteroides species including the B. fragilis group.